Over-the-Counter and Herbal Remedies for Weight Loss (Cleveland Clinic)

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Appetite suppressants: Appetite suppressants work by "tricking" the body into thinking that it is not hungry. This can be effective; however, long term use can lead to addiction and create health complications. These drugs are only good for as long as you are taking them. In order to lose weight effectively, you must learn to adjust your eating habits, otherwise you will simply regain any lost weight. Recently, the FDA has taken steps to remove phenylpropanolamine (PPA), a common weight loss ingredient in appetite suppressants, from all drug products and has requested that all drug companies discontinue marketing products containing PPA. Recent studies have linked PPA an increased risk of stroke. The FDA warns consumers to avoid use of products containing PPA.

Ephedrine (ma-huang): Ephedrine is a common ingredient in herbal dietary supplements used for weight loss. Ephedrine is used in asthma medicine, as well as to make methamphetamine, more commonly known as speed. In fact, there's only a slight chemical difference between methamphetamine and ephedrine. Ephedrine can slightly suppress your appetite, but no studies have shown it to be effective in weight loss. However, ephedrine can also be dangerous and cause high blood pressure, heart rate irregularities, insomnia, nervousness, tremors, seizures, heart attacks, strokes, and even death. Ephedrine can also interact with many prescription and over-the-counter medications.

St. John's Wort: Primarily used as an antidepressant due to its effects on serotonin (increases), most of the studies conducted on this herbal medicine have been very small and have not been for weight loss. These studies have been to assess the effectiveness of this agent in the management of depression. St. John’s Wort is one of the primary ingredients in herbal phen-fen. If you are taking St. John’s wort, you should avoid tyramine-containing foods (i.e., aged meats, cheese, wines, etc). You should also avoid medications such as fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), venlafaxine (Effexor), trazodone (Desyrel), mirtazapine (Remeron), nefazodone (Serzone), meperidine (Demerol), buspirone (Buspar), and dextromethorphan (contained in various OTC cold remedies). The use of St. John's Wort for weight loss is theoretical and potentially very dangerous. It should be avoided as an herbal remedy for weight loss.

5-hydroxytryptophan (5-HTP): Found in some over-the-counter weight loss formulas, this extract from a West African plant seed contains a contaminant linked to a rare and potentially deadly blood disorder. It has not been proven to effectively promote weight loss.

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Last Updated: 3/24/2010

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