These medicines are also called tumor necrosis factor
antagonists (TNF antagonists).
Alefacept is given once a week in
an IV () or once a week as a shot in a muscle.
Dosage depends on your body weight. The treatment usually lasts for 12
Etanercept is usually given once a week as a shot under the
skin. Adalimumab is given as a shot under the skin every other week. Some
people learn to give themselves the shots at home. Your dosage depends on your body
Infliximab is given in three 2-hour IV (intravenous) doses
in the doctor's office in the first 6 weeks, then every 4 to 6 weeks.
How It Works
Biologics block harmful responses from the
that lead to the symptoms of
Why It Is Used
Biologics are used to treat
moderate to severe
chronic plaque psoriasis and
. Alefacept, etanercept, and
infliximab are all approved by the U.S. Food and Drug Administration (FDA) for
the treatment of psoriasis. Adalimumab, etanercept, golimumab, and infliximab
have been approved for treating
How Well It Works
These biologics significantly reduce
symptoms of psoriasis, providing rapid and sustained improvement. Continued
treatment can lead to extended remission from symptoms., , ,
One study showed that etanercept was effective for treating psoriasis in children.
The most common side effect of these
biologics is an allergic reaction to the injection (shot) or infusion (medicine
given in a vein, intravenously, or IV). If you have a reaction to the shot or
infusion, it will happen right away, either during the infusion or within 1 to
2 hours after the infusion or shot. Your doctor may give you medicines to
prevent or stop the reaction.
Symptoms of a shot or infusion site
- Fever and chills.
pain and shortness of breath.
- Heat and
redness (flushing) in the
- Fatigue and dizziness.
Warnings have been issued about serious side effects of
these biologics. The U.S. Food and Drug Administration (FDA) and the medicine’s
manufacturers have warned about:
- An increased risk of a serious infection. TNF antagonists affect
your body's ability to fight all infections. So if you get a fever, cold, or
the flu while you are taking this medicine, let your doctor know right
- An increased risk of blood or nervous system disorders. Call
your doctor if you have symptoms of blood disorders (such as bruising or
bleeding) or symptoms of nervous system problems (such as numbness, weakness,
tingling, or vision problems).
- A possible increased risk of
(a type of blood cancer). It is not clear
whether this increase is because of the drug or because people with this
disease may already have a higher risk. There have
been reports of a rare kind of lymphoma, occurring mostly in children and teens
taking some of these biologics, that often results in death.
increased risk of liver injuries. Call your doctor if your skin starts to look
yellow, if you are very tired, or if you have dark brown urine and/or a