Pain Medicines

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Pain treatments come in both non-prescription form and those available only by prescription.

Pain treatments: Non-prescription

What are OTC pain medicines?
Over-the-counter (OTC) medicines are those that are available without a prescription from a doctor. Some examples of OTC pain relievers are acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs). Acetaminophen products include Tylenol®. NSAIDs include aspirin, ibuprofen (Motrin®), ketoprofen (Orudis®KT), and naproxen sodium (Aleve®. Some products contain both aspirin and acetaminophen (Extra Strength Excedrin ®).

Both acetaminophen and NSAIDs reduce fever and relieve pain caused by muscle aches and stiffness, but only NSAIDs can also reduce inflammation (swelling and irritation).

Acetaminophen and NSAIDs also work differently. NSAIDs relieve pain by reducing the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Acetaminophen works on the parts of the brain that receive the "pain messages."

What are topical pain relievers?
OTC pain treatments also include topical pain relievers. These products include creams, lotions, or sprays that are applied to the skin to relieve pain from sore muscles and arthritis. Some examples of topical pain relievers include the brands Aspercreme® and Ben-Gay®. Some topical treatments contain a medicine such as aspirin, but there is no evidence that topical aspirin effectively relieves pain.

Other topical medicines "mask" the feelings of pain by making the skin feel warm or cold. An example is capsaicin, which comes from the extracts of chili peppers.

Some topical treatments block the "pain message" from reaching the brain. In general these medicines are safe, even for long-term use.

Pain treatments: Prescription

What are corticosteroids?
Corticosteroids are cortisone-like medicines that are used to provide relief for inflamed areas of the body. These medicines help to ease swelling, redness, itching, and allergic reactions. Often, corticosteroids are used for conditions such as allergies, asthma, and arthritis. Corticosteroids are similar to the natural corticosteroid hormones that are produced by the cortex (outer part) of the adrenal glands. Some corticosteroids are available over the counter, such as lower-strength hydrocortisone creams (Cortaid®, Cortizone®).

Other common types of corticosteroids require prescriptions. These include:

  • Prednisone
  • Prednisolone
  • Methylprednisolone
  • Dexamethasone

Prescription corticosteroids are strong medicines that may cause serious side effects. Side effects may include weight gain, diabetes, upset stomach, headache, mood changes, and trouble sleeping. These medicines might also make it harder for the body to fight off infections. Efforts are under way to develop safer corticosteroids.

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Last Updated: 6/12/2007

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