Osteoporosis (Cleveland Clinic)

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What is osteoporosis?
Osteoporosis is a disease that weakens bones, making them more susceptible to sudden and unexpected fractures. Literally meaning "porous bone," it results in an increased loss of bone mass and strength. The disease often progresses without any symptoms or pain. Generally, it is not discovered until weakened bones cause painful fractures. Most of these are fractures of the hip, wrist and spine.

Though osteoporosis occurs in both men and women, women are four times more likely to develop the disease than men. Thankfully, there are steps you can take to prevent osteoporosis from ever occurring. Treatments can also slow the rate of bone loss if osteoporosis is present.

What causes osteoporosis?
Though we do not know the exact cause of osteoporosis, we do understand how the disease develops. Your bones are made of living, growing tissue. An outer shell of cortical or dense bone encases trabecular or spongy bone. The inside of healthy bone resembles a sponge. When osteoporosis occurs, the "holes" in the "sponge" grow larger and more numerous, weakening the internal structure of the bone.

In addition to supporting the body and protecting vital organs, bones store calcium and other minerals. When the body needs calcium, it breaks down and rebuilds bone. This process, called "bone remolding," supplies the body with needed calcium while keeping the bones strong.

Up until about age 30, a person normally builds more bone than he or she loses. After age 35, bone breakdown outpaces bone buildup, resulting in a gradual loss of bone mass. In a person with osteoporosis, bone mass is lost at an accelerated rate.

Who is most at risk for developing osteoporosis?
There are many risk factors which, when present, increase your chance of developing osteoporosis.

Gender--Women over the age of 50 have the greatest risk of developing osteoporosis. Women experience rapid bone loss during and 5 to 10 years after menopause. Menopause decreases the production of estrogen, a hormone which protects against excess bone loss.

Age--Your risk for osteoporosis increases as you age.

Race--Women of Caucasian and Asian descent are more likely to develop osteoporosis.

Bone structure and body weight--Petite and thin people have a greater risk of developing osteoporosis because they have less bone to lose than people with more body weight and larger frames.

Family history--If your parents or grandparents have had any signs of osteoporosis, such as a fractured hip after a minor fall, you may have a greater risk of developing the disease.

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Last Updated: 3/18/2009

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