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This topic provides information about sudden kidney failure. If you are looking for information about long-term kidney disease, see the topic Chronic Kidney Disease.

What is acute renal failure?

Acute renal failure (also called acute kidney injury) means that your kidneys have suddenly stopped working. Your kidneys remove waste products and help balance water and salt and other minerals (electrolytes) in your blood. When your kidneys stop working, waste products, fluids, and electrolytes build up in your body. This can cause problems that can be deadly.

What causes acute renal failure?

Acute renal failure has three main causes:

• A sudden, serious drop in blood flow to the kidneys. Heavy blood loss, an injury, or a bad infection called sepsis can reduce blood flow to the kidneys. Not enough fluid in the body (dehydration) also can harm the kidneys.
• Damage from some medicines, poisons, or infections. Most people don't have any kidney problems from taking medicines. But people who have serious, long-term health problems are more likely than other people to have a kidney problem from medicines. Examples of medicines that can sometimes harm the kidneys include:
  • Antibiotics, such as gentamicin and streptomycin.
  • Pain medicines, such as aspirin and ibuprofen.
  • Some blood pressure medicines, such as ACE inhibitors.
  • The dyes used in some X-ray tests.
• A sudden blockage that stops urine from flowing out of the kidneys. Kidney stones, a tumor, an injury, or an enlarged prostate gland can cause a blockage.

You have a greater chance of getting acute renal failure if:

• You are an older adult.
• You have a long-term health problem such as kidney or liver disease, diabetes, high blood pressure, heart failure, or obesity.
• You are already very ill and are in the hospital or intensive care (ICU). Heart or belly surgery or a bone marrow transplant can make you more likely to have kidney failure.

What are the symptoms?

Symptoms of acute renal failure may include:

• Little or no urine when you urinate.
• Swelling, especially in your legs and feet.
• Not feeling like eating.
• Nausea and vomiting.
• Feeling confused, anxious and restless, or sleepy.
• Pain in the back just below the rib cage. This is called flank pain.

Some people may not have any symptoms. And for people who are already quite ill, the problem that's causing the kidney failure may be causing other symptoms.