Examples

How It Works

Aldosterone receptor antagonists are medicines that help the body get rid of extra water (diuretics). They also have other properties that can prevent heart failure from becoming worse, along with improving symptoms of heart failure.

These medicines cause the kidneys to get rid of extra water and they help hold on to (retain) potassium by inhibiting the action of the hormone aldosterone. Because of this, they are called potassium-sparing diuretics.

Why It Is Used

Aldosterone receptor antagonist medicines may be a good option for people with severe heart failure who are already taking other medicines (such as angiotensin-converting enzyme [ACE] inhibitors, other diuretics, digoxin, and beta-blockers).¹

How Well It Works

Aldosterone receptor antagonists are the only diuretics that improve survival for people with heart failure. They lower the risk of death and hospitalization and improve symptoms of heart failure.²

More research is needed to confirm the usefulness of this medicine in treating less severe forms of heart failure.

Side Effects

All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

• Usually the benefits of the medicine are more important than any minor side effects.
• Side effects may go away after you take the medicine for a while.
• If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call 911 or other emergency services right away if you have:

• Trouble breathing.
• Hives.
• Swelling of your face, lips, tongue, or throat.
• Confusion.
• Irregular heartbeat.
• Numbness or tingling in your hands, feet, or lips.

Common side effects of this medicine include:

• Nausea and vomiting.
• Stomach cramps.
• Diarrhea.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

You may feel more tired or need to urinate more often when you start taking this medicine. These effects typically occur less after you have taken the medicine for a while. If the increase in urine interferes with your sleep or daily activities, ask your doctor to help you plan a schedule for taking the medicine.