Migraine Headaches (Cleveland Clinic)

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What is a migraine headache?
A migraine headache is considered a vascular headache because it is associated with changes in the size of the arteries within and outside of the brain.

Who is affected by migraines?
The National Headache Foundation estimates that nearly 30 million Americans suffer from migraines. Migraines occur about three times more frequently in women than in men. Each migraine can last from four hours to three days. Occasionally, it will last longer.

What causes a migraine?
The exact causes of migraines are unknown, although they are related to changes in the brain as well as to genetic causes. People with migraines may inherit the tendency to be affected by certain migraine triggers, such as fatigue, bright lights, weather changes and others.

For many years, scientists believed that migraines were linked to the expanding (dilation) and constriction (narrowing) of blood vessels on the brain’s surface. However, it is now believed that migraine is caused by inherited abnormalities in certain areas of the brain.

There is a migraine "pain center" or generator in the mid-brain area. A migraine begins when hyperactive nerve cells send out impulses to the blood vessels, causing constriction, followed by the dilation of these vessels and the release of prostaglandins, serotonin and other inflammatory substances that cause the pulsation to be painful.

Certain brain cells that use serotonin as a messenger are involved in controlling mood, attention, sleep, and pain. Therefore, chronic changes in serotonin can lead to anxiety, panic disorder, and depression.

What triggers a migraine?
Many migraines seem to be triggered by external factors. Migraine sufferers can help the physician identify these triggers. Possible triggers include:

  • Emotional stress is one of the most common triggers of migraine headache. Migraine sufferers generally are highly affected by stressful events. During stressful events, certain chemicals in the brain are released to combat the situation (know as the "flight or fight" response). The release of these chemicals can provoke vascular changes that can cause migraine. Repressed emotions surrounding stress, such as anxiety, worry, excitement and fatigue can increase muscle tension and dilated blood vessels can intensify the severity of migraine.
  • Sensitivity to specific chemicals and preservatives in foods. Certain foods and beverages, such as aged cheese, alcoholic beverages, and food additives such as nitrates (in pepperoni, hot dogs, luncheon meats) and monosodium glutamate (MSG, commonly found in Chinese food) may be responsible for triggering up to 30% of migraines.
  • Caffeine. Excessive caffeine consumption or withdrawal from caffeine can cause headaches when the caffeine level abruptly drops. The blood vessels seem to become sensitized to caffeine, and when caffeine is not ingested, a headache may occur. Caffeine itself is often helpful in treating acute migraine attacks.
  • Changing weather conditions such as storm fronts, barometric pressure changes, strong winds or changes in altitude
  • Menstrual periods
  • Tension
  • Excessive fatigue
  • Missing meals
  • Changes in normal sleep pattern

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Last Updated: 9/1/2006

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