Caffeine and Headache (Cleveland Clinic)

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Caffeine can be a double-edged sword for those with headache--it can serve as a treatment or, in some cases, can cause withdrawal or a phenomenon known as "rebound" headache. The important thing to remember is that with education and moderation, caffeine can be one of the most effective treatments for headache.

Caffeine as a headache treatment
Caffeine is a common ingredient in many prescription and over-the-counter headache medications (see list below). Because analgesics work more quickly and more efficiently with caffeine, patients are able to take less medication. Caffeine additives make pain relievers 40% more effective. Caffeine also helps the body absorb medications more quickly, allowing the patient to feel relief sooner. By adding caffeine and, in turn, taking less medication, the patient reduces the risk for potential side effects and reduces the risk of habitual or addictive usage.

Common Over-the-Counter Drugs Containing Caffeine

Drug NameCaffeine Content
Anacin Maximum Strength32 mg.
Anacin Tablets and Caplets32 mg.
Aspirin-Free Excedrin Caplets65 mg.
Excedrin Extra Strength Caplets and Tablets65 mg.
Excedrin Migraine65 mg.
Goody's Extra Strength Tablets16.25 mg.
Goody's Extra Strength Headache Powder32.50 mg.
Goody's Cool Orange Powder65 mg.
Midol Menstrual Maximum Strength Caplets60 mg.
NoDoz Maximum Strength200 mg.
Pain Reliever Plus Tablets65 mg.
Vanquish Caplets33 mg.
Vivarin200 mg.

Common Prescription Drugs Containing Caffeine

Drug NameCaffeine Content
Ergotamine/Caffeine Suppositories (Migergot)100 mg.
Ergotamine/Caffeine Tablets (Cafergot)100 mg.
Fiorinal Capsules40 mg.
Fiorinal with Codeine Capsules40 mg.
Fioricet Tablets40 mg.
Orphenadrine Citrate, Aspirin and Caffeine (Norgesic )30 mg.
Orphenadrine Citrate, Aspirin and Caffeine (Norgesic Forte)60 mg.
Synalgos-DC30 mg.

Note: The drugs listed are some of the more common drugs containing caffeine; all medications containing caffeine are not included. Always check the labels of over-the-counter medications for caffeine content. Or, ask your health care provider or pharmacist about the caffeine content of your medications.

Caffeine sources

Beverages

  • Chocolate milk, chocolate milkshakes, hot chocolate and chocolate drinks
  • Cocoa mix, malt powder, chocolate flavoring
  • Cola and other sodas, like Mountain Dew (regular and diet)
  • Coffee
  • Tea
  • Chocolate or coffee liqueurs

Note: Caffeine-free and decaffeinated beverages also contain small amounts of caffeine.

Foods

  • All chocolate products including brownies, cake, eclairs
  • Chocolate candy including fudge and chocolate-covered coconut, raisins, and peanuts
  • Chocolate-covered graham crackers (or chocolate-flavored graham crackers)
  • Chocolate ice cream or pudding

Caffeine and Withdrawal
Caffeine withdrawal from normal caffeine usage is rare. However, with excess use, over 500 mg daily (approximately 5 cups of coffee) over a long period of time, sudden cessation could cause symptoms of withdrawal. Patients can avoid caffeine withdrawal by limiting their daily consumption, being educated about sources of caffeine and by gradually decreasing the consumption rather than ending use abruptly.

Caffeine and Rebound Headache
Rebound headache is a condition that develops from the overuse or misuse of any headache medication, including caffeine-containing medication. While caffeine-containing medications can be beneficial, these medications--combined with consuming caffeine (coffee, tea, soft drinks or chocolate) from other sources--make you more vulnerable to a rebound headache.

Relief from rebound headache can only be accomplished by completely quitting all headache medication. However, this should only be done under the supervision of a physician.

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Last Updated: 4/6/2011

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