Who Should Be Evaluated for Epilepsy Surgery?

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What is epilepsy surgery?
Epilepsy surgery involves a brain operation to control epileptic seizures. Different types of epilepsy require different types of operations.

Who is a candidate for epilepsy surgery?
In general, epilepsy surgery may be considered in people of any age, from infancy to adulthood. The best candidates for epilepsy surgery are:

  • People with epileptic seizures that cannot be controlled satisfactorily with medication and whose lives would be improved if seizures were controlled. The definition of "satisfactory" control varies from person to person.
  • People with a brain abnormality that can be identified as the cause of seizures. Some abnormalities such as brain tumors may require surgery even if seizures are well controlled with medication.

Which types of epilepsy respond to surgery?
1. Focal resective surgery is performed in people with partial epilepsy, in which seizures arise from a small part of the brain. It involves removing a small part of the brain, with the intent of sparing important neurological functions such as movement, sensation, speech, and memory. The most common location of surgery is in the temporal lobe (under the temple). Partial epilepsy may be caused by a scar from birth, injury or head trauma, brain tumors, arteriovenous vascular malformations (a tangle of blood vessels resulting in fewer than normal connections between capillaries), infections, or abnormal brain development.

2. Hemispherectomy is performed in people with abnormalities of one hemisphere (side) of the brain. Conditions such as Sturge-Weber disease, Rasmussen’s encephalitis, hemimegalencephaly, or perinatal stroke may injure a large area on just one side of the brain. People with these disorders typically have severe neurologic problems, such as paralysis and loss of sensation on one side of the body. With this procedure, a portion of the damaged brain is removed, and the rest of the hemisphere is disconnected from the good portions of the brain to prevent the seizures from spreading.

3. Callosotomy involves cutting part of the corpus callosum, a large bundle of nerve fibers that connect the two sides of the brain. The goal is to prevent spreading of seizures from one side of the brain to the other. Callosotomy is usually performed in people with severe generalized tonic (stiffening) or atonic (limp) seizures that cause falling and injuries ("drop attacks").

4. Subdural electrode insertion involves placing electrode arrays directly in contact with the brain in order to better localize the region(s) of the brain responsible for seizure onset. They also can be used to stimulate the underlying brain tissue and document the presence of cortex that supports important motor or language function. This technique is especially useful in patients who have medically intractable epilepsy and normal anatomy documented by magnetic resonance imaging.

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Last Updated: 4/16/2008

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