Pyrazinamide is an antibiotic. The exact way that pyrazinamide works is unknown.

Pyrazinamide is used to treat tuberculosis (TB).

Pyrazinamide may also be used for purposes other than those listed in this medication guide.

Take all of the pyrazinamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Call your doctor immediately if you experience a fever, loss of appetite, nausea and vomiting, painful or swollen joints, yellowing of your skin or eyes, or darkening of your urine.

Before taking pyrazinamide, tell your doctor if you have

• ever had an allergic reaction to pyrazinamide,

• liver disease,

• gout,

• kidney disease, or

• diabetes mellitus.

You may not be able to take pyrazinamide, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Pyrazinamide is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Pyrazinamide passes into breast milk and may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.