Podophyllum resin topical is a skin medication made from a powdered mixture of extracts from a plant called Mandrake, or May apple.

Podophyllum resin topical is used to treat genital warts on the outside of the penis or vagina, or on the skin between the rectum and the genitals.

Podophyllum resin topical may also be used for other purposes not listed in this medication guide.

This medication can cause birth defects. Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment.

You should not use this medication if you are allergic to podophyllum resin topical.

You may not be able to use podophyllum resin topical if you have certain conditions. Tell your doctor if you a pregnant or breast-feeding, or if you have diabetes, circulation problems, Raynaud's syndrome, or if you use steroid medications.

Do not use podophyllum resin topical in larger amounts or for longer than recommended. Using more of the medication than prescribed will not make it work better, and may increase your risk of unpleasant side effects.

Do not use this medication to treat genital warts inside the rectum, vagina, or penis. Do not apply to bleeding, swollen or irritated skin. Do not use on moles, birthmarks, or any wart your doctor has not instructed you to treat with podophyllum resin.

Avoid getting this medication in your eyes. It can cause severe irritation. If the medication does get in your eyes, rinse with plenty of water and call a doctor right away.

Genital warts are contagious. Avoid having unprotected sex if you have genital warts. Using podophyllum resin will not prevent you from passing genital warts to other people. Talk with your doctor about safe methods of preventing transmission during sex, such as using a condom.

You should not use this medication if you are allergic to podophyllum resin topical.

Before using podophyllum resin topical, tell your doctor if you have:

• diabetes;

• circulation problems;

• Raynaud's syndrome;

• if you use steroid medications such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others; or

• if you are pregnant or breast-feeding.

If you have any of these conditions, you may not be able to use podophyllum resin topical, or you may need a dose adjustment or special tests during treatment.

FDA pregnancy category X. This medication can cause birth defects. Do not use podophyllum resin topical if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication.

It is not known whether podophyllum resin passes into breast milk or if it could harm a nursing baby. Do not use this medication if you are breast-feeding a baby.