Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dihydrocodeine is a narcotic cough suppressant similar to codeine. Dihydrocodeine affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, dihydrocodeine, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine, dihydrocodeine, and pseudoephedrine may also be used for purposes not listed in this medication guide.

You should not use this medication if you are allergic to chlorpheniramine, dihydrocodeine, pseudoephedrine, or codeine, or if you have severe or uncontrolled high blood pressure, severe coronary artery disease, narrow-angle glaucoma, a stomach ulcer, a bowel obstruction called paralytic ileus, bladder obstruction or other urination problems, overactive thyroid, or asthma, pneumonia, or other breathing problems.

Before you take chlorpheniramine, dihydrocodeine, and pseudoephedrine, tell your doctor about all of your medical conditions and other medicines you use.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Antihistamines, decongestants, and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, or cough suppressant.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

You should not use this medication if you are allergic to chlorpheniramine, dihydrocodeine, pseudoephedrine, or codeine, or if you have:

• severe or uncontrolled high blood pressure;

• severe coronary artery disease;

• narrow-angle glaucoma;

• a stomach ulcer;

• a bowel obstruction called paralytic ileus;

• bladder obstruction or other urination problems;

• overactive thyroid; or

• asthma, pneumonia, or other breathing problems.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take chlorpheniramine, dihydrocodeine, and pseudoephedrine, tell your doctor if you have any of these other conditions:

• kidney or liver disease;

• curvature of the spine;

• heart disease or high blood pressure;

• enlarged prostate or urination problems;

• diabetes;

• glaucoma;

• a thyroid disorder;

• COPD other breathing disorder;

• a history of head injury or brain tumor;

• epilepsy or other seizure disorder;

• low blood pressure;

• gallbladder disease;

• Addison's disease or other adrenal gland disorders;

• mental illness; or

• a history of drug or alcohol addiction.

Dihydrocodeine may be habit forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Dihydrocodeine may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using chlorpheniramine, dihydrocodeine, and pseudoephedrine.

This medicine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using chlorpheniramine, dihydrocodeine, and pseudoephedrine.