Acetaminophen is a pain reliever and a fever reducer.

Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.

Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

The combination of acetaminophen, aspirin, and caffeine is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.

Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.

Acetaminophen, aspirin, and caffeine may also be used for purposes not listed in this medication guide.

Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

You should not use this medication if you are allergic to acetaminophen (Tylenol), aspirin, or caffeine, or if you have liver disease, stomach or intestinal bleeding, a history of asthma or severe allergic reaction to aspirin or an NSAID (non-steroidal anti-inflammatory drug).

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take acetaminophen.

Ask a doctor or pharmacist about using acetaminophen, aspirin, and caffeine if you have asthma or seasonal allergies, fever with a stiff neck, a stomach ulcer or pain, heartburn, a bleeding or blood clotting disorder, diabetes, or gout.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Stop using this medication and call your doctor at once if you have any symptoms of liver damage or bleeding in your stomach or intestines. Symptoms of liver damage include nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes). Symptoms of stomach bleeding include weakness or fainting, bloody or tarry stools, and coughing up blood or vomit that looks like coffee grounds.

Avoid drinking alcohol while you are taking this medication. Alcohol may increase your risk of stomach bleeding while taking aspirin, or liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cough, cold, allergy, pain, menstrual symptom, or fever medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Aspirin and caffeine are also contained in many combination medicines. Check the label to see if a medicine contains acetaminophen, APAP, aspirin, or caffeine.

Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take acetaminophen.

You should not use this medication if you are allergic to acetaminophen (Tylenol), aspirin, or caffeine, or if you have:

• a recent history of stomach or intestinal bleeding;

• liver disease;

• asthma or severe allergic reaction caused by taking aspirin or an NSAID (non-steroidal anti-inflammatory drug), especially "aspirin triad syndrome"; or

• if you are allergic to an NSAID such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

Ask a doctor or pharmacist if it is safe for you to take acetaminophen, aspirin, and caffeine if you have:

• asthma or seasonal allergies;

• fever with a stiff neck;

• a stomach ulcer, heartburn, or stomach pain;

• a bleeding or blood clotting disorder such as hemophilia;

• diabetes; or

• gout.

If you take acetaminophen, aspirin, and caffeine to treat headache pain, seek medical attention if you have:

• a headache so bad you have to lie down;

• a headache that causes vomiting;

• what feels like the worst headache you've ever had;

• a headache that seems different from your usual headaches;

• a headache every day;

• a headache after coughing, bending, exercising, or head injury;

• if you have never had migraines diagnosed by a doctor; or

• if you are having your first headache after age 50.

Aspirin may be harmful to an unborn baby's heart, and may also reduce birth weight or have other dangerous effects. Tell your doctor if you are pregnant or plan to become pregnant while you are taking acetaminophen, aspirin, and caffeine.

Aspirin, acetaminophen, and caffeine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.