Dienogest and estradiol is a combination of female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Dienogest and estradiol is used as contraception to prevent pregnancy.

Dienogest and estradiol may also be used for purposes not listed in this medication guide.

Smoking can increase your risk of blood clots, stroke, or heart attack caused by birth control pills, especially if you are older than 35.

This medication can harm an unborn baby or cause birth defects. Do not use dienogest and estradiol if you are pregnant.

Do not use this medication if you have a history of heart attack or stroke, a history of blood clot or coronary artery disease, circulation problems (especially if caused by diabetes), a blood clotting disorder, breast or uterine cancer, abnormal vaginal bleeding, eye problems or kidney problems caused by diabetes, liver disease or liver cancer, uncontrolled high blood pressure, severe migraine headaches, a heart valve or heart rhythm disorder, or if you smoke and you are over 35 years old.

Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all medications you use.

This medication can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills.

Do not use this medication if you are allergic to dienogest or estradiol, or if you have:

• a history of heart attack, stroke, blood clot, or coronary artery disease;

• a blood-clotting disorder, untreated or uncontrolled high blood pressure;

• a hormone related cancer such as breast or uterine cancer;

• abnormal vaginal bleeding;

• problems with your eyes, kidneys, or circulation caused by diabetes;

• liver disease or liver cancer;

• severe migraine headaches;

• a heart valve or heart rhythm disorder; or

• if you smoke and you are over 35 years old.

To make sure you can safely take this medicine, tell your doctor if you have any of these other conditions:

• high blood pressure, heart disease, congestive heart failure, high cholesterol or triglycerides;

• a history of depression;

• diabetes;

• underactive thyroid; or

• a history of jaundice caused by birth control pills.

The hormones in this medication can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast feeding a baby.