What is sumatriptan and naproxen?
Sumatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain.
Naproxen is a nonsteroidal anti-inflammatory drugs (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body.
The combination of sumatriptan and naproxen is used to treat migraine headaches.
Sumatriptan and naproxen will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Sumatriptan and naproxen may also be used for purposes not listed in this medication guide.
What is the most important information I should know about sumatriptan and naproxen
Do not take more than 2 sumatriptan and naproxen tablets in 24 hours.
You should not use this medication if you are allergic to sumatriptan (Imitrex) or naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs). Do not take if you have liver disease, uncontrolled high blood pressure, or a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery.
Do not take sumatriptan and naproxen within 24 hours before or after taking any of the following medications: almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig), or ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).
What should I discuss with my health care provider before taking sumatriptan and naproxen?
You should not use this medication if you are allergic to sumatriptan (Imitrex), naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.
Do not take sumatriptan and naproxen if you have:
liver disease;
untreated or uncontrolled high blood pressure; or
a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery (also called coronary artery bypass graft, or CABG).
Do not take sumatriptan and naproxen if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the past 14 days.
Do not take sumatriptan and naproxen within 24 hours before or after taking any of the following medicines:
almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).
To make sure you can safely take sumatriptan and naproxen, tell your doctor if you have any of these other conditions:
epilepsy or other seizure disorder;
kidney disease;
high blood pressure, congestive heart failure; or
coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
FDA pregnancy category C. Taking naproxen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Sumatriptan and naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medication.