Chlorpheniramine and phenyltoloxamine are antihistamines. They block the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine and phenyltoloxamine prevent sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylephrine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.

Chlorpheniramine, phenyltoloxamine, and phenylephrine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Chlorpheniramine, phenyltoloxamine, and phenylephrine may also be used for purposes other than those listed in this medication guide.

Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpheniramine, phenyltoloxamine, and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking chlorpheniramine, phenyltoloxamine, and phenylephrine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

Do not take chlorpheniramine, phenyltoloxamine, and phenylephrine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• kidney disease,

• liver disease,

• diabetes,

• glaucoma,

• heart disease or high blood pressure,

• thyroid disease,

• emphysema or chronic bronchitis, or

• difficulty urinating or an enlarged prostate.

You may not be able to take chlorpheniramine, phenyltoloxamine, and phenylephrine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Chlorpheniramine, phenyltoloxamine, and phenylephrine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

This medication passes into breast milk and may harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from chlorpheniramine, phenyltoloxamine, and phenylephrine. You may require a lower dose of this medication.

Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.