Apraclonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Apraclonidine ophthalmic is used to treat or prevent high pressure inside the eye caused by certain types of eye surgery or procedures.

Apraclonidine ophthalmic may also be used for other purposes not listed in this medication guide.

Do not use apraclonidine ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using apraclonidine ophthalmic, tell your doctor if you have kidney or liver disease, heart disease, high blood pressure, or a history of fainting or low blood pressure. Also tell your doctor if you are using any medications to treat high blood pressure or a heart rhythm disorder.

You should not use this medication if you are allergic to apraclonidine or to clonidine (Catapres).

Do not use apraclonidine ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using apraclonidine ophthalmic, tell your doctor if you have:

• kidney disease;

• liver disease;

• heart disease or high blood pressure;

• a history of fainting or low blood pressure.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use apraclonidine ophthalmic.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether apraclonidine ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.