Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

The combination of ibuprofen and oxycodone is used short-term to relieve moderate to severe pain.

Ibuprofen and oxycodone may also be used for purposes not listed in this medication guide.

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use ibuprofen and oxycodone just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen and oxycodone, especially in older adults. Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Oxycodone may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Tell your doctor if the medicine seems to stop working as well in relieving your pain.

You should not use this medication if you have severe or uncontrolled asthma, or a stomach condition called paralytic ileus. Do not use ibuprofen and oxycodone just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Oxycodone may be habit forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen and oxycodone, especially in older adults.

Do not use this medication if you are allergic to oxycodone or ibuprofen (Advil, Motrin), or other NSAIDs such as aspirin, Aleve, Celebrex, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

To make sure you can safely take ibuprofen and oxycodone, tell your doctor if you have any of these other conditions:

• heart disease, congestive heart failure, high blood pressure, or a history of heart attack, stroke, or blood clot;

• asthma or other breathing disorders;

• liver or kidney disease;

• a history of head injury or brain tumor;

• epilepsy or other seizure disorder;

• stomach or intestinal disorder, history of stomach ulcer or bleeding;

• underactive thyroid, a pancreas disorder, or Addison's disease or other adrenal gland disorder;

• curvature of the spine;

• an enlarged prostate or problems with urination; or

• mental illness or a history of drug or alcohol addiction.

FDA pregnancy category D. Oxycodone may cause breathing problems and addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using ibuprofen and oxycodone.

Ibuprofen and oxycodone may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medicine.