Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough suppressant.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of dexbrompheniramine, hydrocodone, and phenylephrine is used to treat nasal congestion, sneezing, runny nose, itchy or water eyes, and cough caused by allergies or the common cold.

Dexbrompheniramine, hydrocodone, and phenylephrine may also be used for other purposes not listed in this medication guide.

Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body.

You should not use dexbrompheniramine, hydrocodone, and phenylephrine if you are allergic to it, or if you have severe or uncontrolled high blood pressure, coronary artery disease, ischemic heart disease (reduced circulation of blood to the heart), narrow-angle glaucoma, peptic ulcer, if you are unable to urinate, or if you are pregnant or breast-feeding.

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children. Dexbrompheniramine, hydrocodone, and phenylephrine should not be given to a child younger than 6 years old.

Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body.

You should not use dexbrompheniramine, hydrocodone, or phenylephrine, if you have ever had an allergic reaction to it, or if you have:

• severe or uncontrolled high blood pressure;

• coronary artery disease;

• an enlarged prostate;

• narrow-angle glaucoma;

• peptic ulcer;

• asthma;

• pheochromocytoma;

• if you are breast-feeding a baby; or

• if you are having an asthma attack.

If you have certain conditions, you may need a dose adjustment or special tests to safely take dexbrompheniramine, hydrocodone, and phenylephrine. Before taking this medication, tell your doctor if you have:

• heart disease or high blood pressure;

• asthma, COPD, or other breathing disorder;

• diabetes;

• glaucoma;

• thyroid disorder;

• a history of head injury or brain tumor;

• enlarged prostate, urination problems.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Hydrocodone can cause breathing problems or addiction/withdrawal symptoms in a newborn. Do not take this medication while you are pregnant.

This medication can pass into breast milk and may harm a nursing baby. Do not take this medication if you are breast-feeding a baby.

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Older adults may be more likely to have side effects from this medication.