Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Fosinopril is an ACE inhibitors. ACE stands for angiotensin converting enzyme. Fosinopril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and fosinopril is used to treat hypertension (high blood pressure) or congestive heart failure.

Hydrochlorothiazide and fosinopril may also be used for purposes not listed in this medication guide.

FDA pregnancy category D. Do not use hydrochlorothiazide and fosinopril if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and fosinopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, glaucoma, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and fosinopril, unless your doctor has told you to.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and fosinopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

To make sure you can safely take hydrochlorothiazide and fosinopril, tell your doctor if you have any of these other conditions:

• kidney disease (or if you are on dialysis);

• liver disease;

• glaucoma;

• gout;

• lupus;

• diabetes; or

• an allergy to sulfa drugs or penicillin.

FDA pregnancy category D. Do not use this medication if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Hydrochlorothiazide and fosinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking hydrochlorothiazide and fosinopril.

Hydrochlorothiazide and fosinopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and fosinopril.