Estramustine is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Estramustine is used to treat metastatic or progressive prostate cancer.

Estramustine may also be used for other purposes not listed in this medication guide.

You should not use this medication if you are allergic to estramustine, or if you have a blood clot, swelling of a vein caused by a blood clot, or if you have ever had an allergic reaction to estradiol or nitrogen mustard.

Before taking estramustine, tell your doctor if you have a history of stroke or heart attack, diabetes, heart disease, high blood pressure, migraine headaches, seizures, liver or kidney disease, or Paget's disease.

Take estramustine on an empty stomach, at least 1 hour before or 2 hours after a meal.

Do not take this medication with milk, milk products, or calcium-rich foods such as ice cream, yogurt, broccoli, and others. Also avoid using antacids or vitamin/mineral supplements that contain calcium. Calcium can make it harder for your body to absorb estramustine, which could make it less effective.

If a man fathers a child while taking estramustine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.

You should not use this medication if you are allergic to estramustine, or if you have:

• a blood clot;

• swelling of a vein caused by a blood clot; or

• if you have ever had an allergic reaction to estradiol or nitrogen mustard.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take estramustine:

• a history of blood clot, stroke, or heart attack;

• diabetes;

• high blood pressure (hypertension);

• heart disease or coronary artery disease (atherosclerosis);

• congestive heart failure;

• migraine headaches;

• epilepsy or other seizure disorder;

• liver disease;

• kidney disease; or

• a metabolic bone disease (such as Paget's disease).

If a man fathers a child while taking estramustine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.