Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Eprosartan is an angiotensin II receptor antagonists. Eprosartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of hydrochlorothiazide and eprosartan is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and eprosartan may also be used for purposes not listed in this medication guide.

FDA pregnancy category D. Do not use hydrochlorothiazide and eprosartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.

Hydrochlorothiazide and eprosartan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and eprosartan.

In rare cases, hydrochlorothiazide and eprosartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

You should not use this medication if you are allergic to eprosartan or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others), or if you are unable to urinate.

To make sure you can safely take hydrochlorothiazide and eprosartan, tell your doctor if you have any of these other conditions:

• kidney disease;

• liver disease;

• glaucoma;

• congestive heart failure;

• low or high levels of potassium in your blood;

• asthma or allergies;

• high cholesterol or triglyceride levels;

• gout;

• lupus;

• diabetes; or

• an allergy to sulfa drugs or penicillin.

FDA pregnancy category D. Do not use this medication if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Eprosartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking hydrochlorothiazide and eprosartan.

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and eprosartan.