This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how aspirin and oxycodone will affect you.

Ask a doctor or pharmacist before using any other over-the-counter cold, allergy, or pain medicine. Aspirin is contained in many combination medicines. Taking certain products together can cause you to get too much aspirin. Check the label to see if a medicine contains aspirin.

Avoid taking acetaminophen (Tylenol) or an NSAID while you are taking aspirin and oxycodone, unless your doctor tells you to. NSAIDs include ibuprofen (Advil, Motrin), ketorolac (Toradol), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking aspirin.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• severe stomach pain or constipation, vomiting;

• black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee ground;

• weak or shallow breathing, fast or slow heartbeats;

• confusion, hallucinations, feeling like you might pass out;

• easy bruising or bleeding;

• seizures; or

• decreased hearing, ringing in your ears.

Less serious side effects may include:

• headache, dizziness, drowsiness;

• constipation, heartburn, upset stomach, bloating, gas, diarrhea; or

• dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ask your doctor before using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), or vilazodone (Viibryd). Taking any of these medicines with aspirin may cause you to bruise or bleed easily.

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy or could slow your breathing (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by aspirin and oxycodone.

Many drugs can interact with aspirin and oxycodone. Below is just a partial list. Tell your doctor if you are using:

• bupropion (Wellbutrin, Zyban);

• deferasirox (Exjade);

• leflunomide (Arava);

• methotrexate (Rheumatrex, Trexall);

• sirolimus (Rapamune) or tacrolimus (Prograf);

• tenofovir (Viread, Atripla, Complera, Truvada);

• antiviral medicines such as adefovir (Hepsera) or cidofovir (Vistide);

• aspirin or other salicylates including Kaopectate, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others;

• bowel cleansing preparations (Half Lytely, Fleet Prep Kit, Evac-Q-Kwik, GoLytely, Supraprep, and others);

• glaucoma medication such as acetazolamide (Diamox) or methazolamide (Glauctabs, Neptazane); or

• medication used to prevent blood clots, such as dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep), and others.

This list is not complete and other drugs may interact with aspirin and oxycodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Your pharmacist can provide more information about aspirin and oxycodone.