Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Dolasetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).

Dolasetron may be used for other purposes not listed in this medication guide.

You should not use this medication if you are allergic to dolasetron or to similar medicines such as ondansetron (Zofran), granisetron (Kytril), or palonosetron (Aloxi).

Before taking dolasetron, tell your doctor if you have a heart rhythm disorder; a personal or family history of Long QT syndrome, or an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

Dolasetron is usually taken 1 hour before chemotherapy or 2 hours before surgery. Tell your doctor if you forget to take the medication within the specified amount of time before your procedure.

You should not use this medication if you are allergic to dolasetron, to similar medicines such as ondansetron (Zofran), granisetron (Kytril), or palonosetron (Aloxi).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take dolasetron:

• a heart rhythm disorder;

• a personal or family history of Long QT syndrome; or

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether dolasetron passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Dolasetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).