Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows the central nervous system.

Isometheptene causes narrowing of blood vessels (vasoconstriction).

The combination of acetaminophen, dichloralphenazone, and isometheptene is used to treat migraine headaches or severe tension headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for purposes not listed in this medication guide.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

You should not take acetaminophen, dichloralphenazone, and isometheptene if you are allergic to acetaminophen (Tylenol), dichloralphenazone, isometheptene, or chloral hydrate (Somnote), or if you have glaucoma or if you are also taking sodium oxybate (Xyrem).

Do not take more than 5 capsules in 12 hours to treat a migraine, or 8 capsules in 24 hours to treat a tension headache.

Ask a doctor or pharmacist before using any other pain, cold, allergy, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Do not use acetaminophen, dichloralphenazone, and isometheptene if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

You should not take this medication if you are allergic to acetaminophen (Tylenol), dichloralphenazone, isometheptene, or chloral hydrate (Somnote), or if you have:

• glaucoma; or

• if you are also taking sodium oxybate (Xyrem).

To make sure you can safely take acetaminophen, dichloralphenazone, and isometheptene, tell your doctor if you have any of these other conditions:

• liver disease or cirrhosis;

• kidney disease;

• coronary artery disease, circulation problems;

• high blood pressure;

• stomach ulcer or problems with your esophagus;

• depression;

• a history of drug or alcohol addiction; or

• if you have recently had a stroke or heart attack.

FDA pregnancy category C. It is not known whether acetaminophen, dichloralphenazone, and isometheptene will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

This medication can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.