Brimonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Timolol also reduces pressure inside the eye.

The combination of brimonidine and timolol ophthalmic (for the eyes) is used to treat glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine and timolol ophthalmic may also be used for other purposes not listed in this medication guide.

Do not use brimonidine and timolol ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

You should not use this medication if you are allergic to brimonidine (Alphagan) or timolol (Timoptic, Cosopt), or if you have certain conditions. Be sure your doctor knows if you have asthma, or severe chronic obstructive pulmonary disease (COPD), heart disease or heart failure, slow heartbeats, or a heart condition called "AV block."

Before using this medication, tell your doctor if you have diabetes, overactive thyroid, circulation problems, allergies, low blood pressure, myasthenia gravis, or a history of depression

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using brimonidine and timolol ophthalmic before putting your contact lenses in.

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use brimonidine and timolol ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

You should not use this medication if you are allergic to brimonidine (Alphagan) or timolol (Timoptic, Cosopt), or if you have certain conditions. Be sure your doctor knows if you have:

• asthma, or severe chronic obstructive pulmonary disease (COPD);

• heart disease or heart failure;

• slow heartbeats; or

• a heart condition called "AV block."

If you have any other conditions, you may need a dose adjustment or special tests to safely use brimonidine and timolol ophthalmic:

• depression;

• diabetes;

• overactive thyroid;

• circulation problems, such as Raynaud's syndrome or Buerger's disease;

• a history of fainting or low blood pressure;

• allergies; or

• a muscle disorder such as myasthenia gravis.

FDA pregnancy category C. It is not known whether brimonidine and timolol ophthalmic is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

Brimonidine and timolol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.