Depression (Cleveland Clinic)

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What is depression?
Nearly everyone has felt depressed, sad, or blue at one time or another. A depressed mood is a normal reaction to loss, life's struggles, or injured self-esteem. Sometimes, however, depression becomes intense, lasts for long periods, and prevents a person from leading a normal life.

What are the symptoms of depression?
The major symptoms of depression include the following:

  • Feeling extremely sad, anxious, or "empty"
  • Feeling hopeless
  • Feeling worthless
  • Having thoughts of death or suicide (If you are having thoughts of suicide, call your local 24-hour suicide hotline right away.)
  • Attempting suicide
  • An increase or decrease in the need for sleep
  • Loss of enjoyment from things that were once pleasurable
  • Loss of energy
  • Difficulty concentrating, thinking, or making decisions
  • Changes in appetite that lead to weight loss or gain

The following physical signs also may be present:

  • Headache
  • Stomach ache
  • Digestive problems
  • Problems with sexual function

Depression that has these characteristics is a medical condition called major depressive disorder, one of a number of depressive illnesses. More than 10 million Americans suffer from major depressive disorder each year, but most never get treatment. When left untreated, depression can become worse, last for years, and cause untold suffering.

If you suffer from depression, it's important to remember that depression is a medical disorder that can be treated successfully.

I have coped with depression before, so why should I seek help?
You may have recognized periods of depression in your life. Perhaps these periods lasted for several months and you learned to cope. But early treatment is important because:

  • Without treatment, depression can become worse.
  • Depression can lead to suicide.
  • Without treatment, people who suffer from episodes of depression often do not fully recover.
  • Treatment can prevent depression from coming back.
  • Your depression may be the sign of another illness, which can worsen without treatment.

What causes depressive disorders?
Depressive disorders result from a mix of factors in a person’s life, including:

  • family history
  • physical health
  • state of mind and environment
  • high levels of stress
  • life transitions
  • loss

Depressive disorders also may be caused by imbalances in the chemicals that the body uses to control mood.

Other causes of depression include:

  • Alcohol and drug abuse
  • Certain medicines
  • Serious physical and mental illnesses
  • Lack of social support
  • Lack of good coping skills
  • Conflicts that have not been resolved
  • Family history of depressive disorder*

*Some people may have an inherited predisposition, or a biological tendency, for developing a depressive disorder. This is thought to be passed down to them as part of their overall makeup.

Copyright © 2010, The CCF Foundation. All rights reserved.


CCF Foundation ("CCF"); Reproduction of Documents in any form is prohibited except with the prior written permission of CCF. CCF does not guarantee the accuracy, adequacy, completeness or availability of any information and is not responsible for any errors or omissions or for the results obtained from the use of such information included in Licensed Content. CCF GIVES NO EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, ANY WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR USE. In no event shall CCF be liable for any indirect, special or consequential damages in connection with subscriber's or others' use of Licensed Content.


Last Updated: 1/24/2008

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