How It Works
to fight infection. These cells
release chemicals that kill both bacteria and surrounding normal cells. After
attacking the bacteria, the white blood cells die, adding to the thickness of
and damaging the lungs of people who have
. Dornase alfa (DNase) helps liquefy
and thin mucus by clearing out
from the dead white blood cells.
DNase is given through a
and is inhaled into the lungs.
Why It Is Used
DNase is used to thin and liquefy
mucus in the lungs of children and adults with cystic fibrosis who have lung
How Well It Works
DNase thins mucus so it can be
coughed up more easily. It improves breathing and reduces the chance of
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
- Usually the benefits of the medicine are more important than any minor side effects.
- Side effects may go away after you take the medicine for a while.
- If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.
Call 911 or other emergency services right away if you have:
- Trouble breathing.
- Swelling of your face, lips, tongue, or throat.
Call your doctor if you have:
Common side effects of this medicine include:
- Chest pain or discomfort.
- Sore throat.
The long-term effects of this drug are not yet
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
DNase must be used regularly for
it to work well.
Do not use DNase solution if it is cloudy or discolored.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.