Breast Cancer Recurrence (Cleveland Clinic)

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When and where do recurrences occur?
Breast cancer can recur at any time, but most recurrences occur in the first three to five years after initial treatment. Breast cancer can come back as a local recurrence (in the treated breast or near the mastectomy scar) or as a distant recurrence somewhere else in the body. The most common sites of recurrence include the lymph nodes, the bones, liver, or lungs.

How do I know there is a recurrence?
Women who have been treated for breast cancer should continue to practice breast self-examination, checking both the treated area and the other breast each month. A woman should report any changes to her doctor right away. Breast changes that might indicate a recurrence include:

  • An area that is distinctly different from any other area on either breast
  • A lump or thickening, in or near the breast or in the underarm, that persists through the menstrual cycle
  • A change in the size, shape, or contour of the breast
  • A mass or lump, which may feel as small as a pea
  • A marble-like area under the skin
  • A change in the feel or appearance of the skin on the breast or nipple [dimpled, puckered, scaly, or inflamed (red, warm, or swollen)]
  • Bloody or clear fluid discharge from the nipples
  • Redness of the skin on the breast or nipple

In addition to performing monthly breast self-exams, keep your scheduled follow-up appointments with your health care provider. During these appointments, your health care provider will perform a breast exam, order lab or imaging tests as needed, and ask you about any symptoms you might have. Initially, these follow-up appointments may be scheduled every three to four months. The longer you are cancer-free, the less often you will need to see your health care provider. Continue to follow your health care provider’s recommendations on screening mammograms (usually recommended once a year).

Prognostic indicators
Prognostic indicators are characteristics of a patient and her tumor that may help a physician predict a cancer recurrence. These are some common indicators:

Lymph node involvement — Women who have lymph node involvement are more likely to have a recurrence.

Tumor size — In general, the larger the tumor, the greater the chance of recurrence.

Hormone receptors — About two-thirds of all breast cancers contain significant levels of estrogen receptors, which means the tumors are estrogen receptor positive (ER+). ER+ tumors tend to grow less aggressively and may respond favorably to treatment with hormones.

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Last Updated: 1/2/2008

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